Automated Computed Tomography analysis in the assessment of Idiopathic Pulmonary Fibrosis severity and progression.

Published on Jan 28, 2020in European Journal of Radiology3.528
· DOI :10.1016/J.EJRAD.2020.108852
Chiara Romei6
Estimated H-index: 6
,
Laura Tavanti8
Estimated H-index: 8
+ 6 AuthorsFabio Falaschi24
Estimated H-index: 24
Sources
Abstract
Abstract Purpose To investigate the role of a quantitative analysis software (CALIPER) in identifying HRCT thresholds predicting IPF patients’ survival and lung function decline and its role in detecting changes of HRCT abnormalities related to treatment and their correlation with Forced Vital Capacity (FVC). Methods This retrospective study included 105 patients with a multidisciplinary diagnosis of IPF for whom one HRCT at baseline and concomitant FVC were available. HRCTs were evaluated with CALIPER and the correlation between FVC and radiological features were assessed. Radiological thresholds for survival prediction and functional decline were calculated for all patients. Fifty-nine patients with at least 2 serial HRCTs were classified into two groups based on treatment. For patients for whom a FVC within 3 months of the HRCT was available (n = 44), the correlation of radiological and clinical progression was evaluated. Results The correlation between FVC and CALIPER-derived features at baseline was significant and strong. A baseline CALIPER-derived interstitial lung disease (ILD%) extent higher than 20% and pulmonary vascular related structures (PVRS%) score greater than 5% defined a worse prognosis. A significant progression of CALIPER-derived features in all patients was found with a faster increase in untreated patients. ILD% and PVRS% changes during follow-up demonstrated strong correlations with FVC changes. Conclusions CALIPER quantification of fibrosis and vascular involvement could distinguish disease progression in treated versus untreated patients and predict the survival. The changes in CALIPER-derived variables over time were significantly correlated to changes in FVC.
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References21
Newest
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with great variability in disease severity and rate of progression. The need for a reliable, sensitive, and objective biomarker to track disease progression and response to therapy remains a great challenge in IPF clinical trials. Over the past decade, quantitative computed tomography (QCT) has emerged as an area of intensive research to address this need. We have gathered a group of pulmonologists, radiologists and scientists with ex...
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#1Simon L.F. Walsh (University of Cambridge)H-Index: 29
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Last. Nicola Sverzellati (University of Parma)H-Index: 51
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Summary Background Based on international diagnostic guidelines, high-resolution CT plays a central part in the diagnosis of fibrotic lung disease. In the correct clinical context, when high-resolution CT appearances are those of usual interstitial pneumonia, a diagnosis of idiopathic pulmonary fibrosis can be made without surgical lung biopsy. We investigated the use of a deep learning algorithm for provision of automated classification of fibrotic lung disease on high-resolution CT according t...
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Rationale: The Scleroderma Lung Study II (SLS II) demonstrated significant improvements in pulmonary function and dyspnea at 24 months compared with baseline when patients with symptomatic sclerode...
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Aims: To determine whether computer-derived computed tomography measures, specifically measures of pulmonary vessel-related structures, can better predict functional decline and survival in idiopathic pulmonary fibrosis (IPF) and reduce requisite sample sizes in drug trial populations. Methods: IPF patients undergoing volumetric non-contrast CT imaging at the Royal Brompton Hospital, London and St Antonius Hospital, Utrecht, were examined to identify pulmonary functional measures (including forc...
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#1Joseph Jacob (Mayo Clinic)H-Index: 27
#2Brian J. Bartholmai (Mayo Clinic)H-Index: 34
Last. Athol U. WellsH-Index: 120
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Objectives To determine whether computer-based CT quantitation of change can improve on visual change quantification of parenchymal features in IPF.
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#1Sang Min Lee (UOU: University of Ulsan)H-Index: 22
#2Joon Beom Seo (UOU: University of Ulsan)H-Index: 32
Last. Namkug Kim (UOU: University of Ulsan)H-Index: 48
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Objectives To retrospectively investigate whether the baseline extent and 1-year change in regional disease patterns on CT can predict survival of patients with idiopathic pulmonary fibrosis (IPF).
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#2Brian J. Bartholmai (Mayo Clinic)H-Index: 34
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Computer-based computed tomography (CT) analysis can provide objective quantitation of disease in idiopathic pulmonary fibrosis (IPF). A computer algorithm, CALIPER, was compared with conventional CT and pulmonary function measures of disease severity for mortality prediction. CT and pulmonary function variables (forced expiratory volume in 1 s, forced vital capacity, diffusion capacity of the lung for carbon monoxide, transfer coefficient of the lung for carbon monoxide and composite physiologi...
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The aim of the study was to determine whether a novel computed tomography (CT) postprocessing software technique (CALIPER) is superior to visual CT scoring as judged by functional correlations in idiopathic pulmonary fibrosis (IPF).A total of 283 consecutive patients with IPF had CT parenchymal patterns evaluated quantitatively with CALIPER and by visual scoring. These 2 techniques were evaluated against: forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), diffusing capacit...
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OBJECTIVE. The aim of our study was to retrospectively determine predictive factors for a decline in forced vital capacity (FVC) on initial CT using texture-based automated quantification in patients with idiopathic pulmonary fibrosis (IPF). MATERIALS AND METHODS. For our study, 193 patients with IPF and 1-year follow-up pulmonary function tests were enrolled in our study. A texture-based automated system used in-house software to quantify six regional CT patterns: normal, ground-glass opacity (...
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Objectives To establish the level of observer variation for the current ATS/ERS/JRS/ALAT criteria for a diagnosis of usual interstitial pneumonia (UIP) on CT among a large group of thoracic radiologists of varying levels of experience. Materials and methods 112 observers (96 of whom were thoracic radiologists) categorised CTs of 150 consecutive patients with fibrotic lung disease using the ATS/ERS/JRS/ALAT CT criteria for a UIP pattern (3 categories—UIP, possibly UIP and inconsistent with UIP). ...
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In patients with IPF, this study aimed (i) to examine the relationship between serial change in CT parameters of lung volume and lung function, (ii) to identify the prognostic value of serial change in CT parameters of lung volume, and (iii) to define a threshold for serial change in CT markers of lung volume that optimally captures disease progression. Serial CTs were analysed for progressive volume loss or fibrosis progression in 81 IPF patients (66 males, median age = 67 years) with concurren...
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Abstract Elucidating the disease process of early idiopathic pulmonary fibrosis (IPF) will help clinicians in addressing the contentious issues of when and in which patients, therapeutic intervention should be initiated. Here, we discuss several possible parameters for diagnosing early IPF and their clinical impacts. Physiologically, early IPF can be considered as IPF with normal or mild impairment in pulmonary function. Radiologically, early IPF can be considered as IPF with a small extent and/...
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