Effect of puerarin on action potential and sodium channel activation in human hypertrophic cardiomyocytes

Volume: 40, Issue: 2
Published: Feb 1, 2020
Abstract
Objective: To study the effect of puerarin on electrophysiology using a hypertrophic cardiomyocyte (HC) model. Materials and methods: Human urine epithelial cells were used to generate the HC model (hiPSC-CM). Cardiomyocyte hypertrophy was induced by applying 10 nM endothelin-1 (ET-1). Effects of puerarin pre-treatment (PPr) and post-treatment (PPo) on action potential, sodium current (INa) activation and inactivation, and recovery following INa...
Paper Details
Title
Effect of puerarin on action potential and sodium channel activation in human hypertrophic cardiomyocytes
Published Date
Feb 1, 2020
Volume
40
Issue
2
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