Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Abstract
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS G13D ) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is...
Paper Details
Title
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Published Date
Jan 24, 2020
Journal
Volume
11
Issue
1
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