Tetrahydroprotoberberines: A Novel Source of Pharmacotherapies for Substance Use Disorders?

The polypharmacology of tetrahydroprotoberberines (THPBs) allows them to target several principal maladaptive behaviors that manifest during different stages of the substance misuse cycle. A subset of THPBs facilitate memory processes that may promote inhibitory control over cue-induced relapse. Low bioavailability and potential for locomotor side effects limit the clinical application of prototypical THPBs. Recent structure–activity...