Blood transfusions during neoadjuvant chemotherapy for muscle-invasive urinary bladder cancer may have a negative impact on overall survival.

Published on Jan 21, 2020in Scandinavian Journal of Urology and Nephrology1.362
· DOI :10.1080/21681805.2020.1716067
Robert Rosenblatt9
Estimated H-index: 9
(KI: Karolinska Institutet),
Gabriella Lorentzi1
Estimated H-index: 1
(Umeå University)
+ 8 AuthorsAmir Sherif26
Estimated H-index: 26
(Umeå University)
Sources
Abstract
AbstractObjective: To evaluate the extent and plausible effects of blood transfusions given during cisplatin-based neoadjuvant chemotherapy (NAC) on overall survival in patients with muscle-invasiv...
References19
Newest
#1David Krantz (KI: Karolinska Institutet)H-Index: 5
#1David Krantz (KI: Karolinska Institutet)H-Index: 5
Last. Ola Winqvist (KI: Karolinska Institutet)H-Index: 45
view all 14 authors...
Evidence indicates that neoadjuvant chemotherapy (NAC) may promote antitumour immune responses by activating T cells. The tumour-draining sentinel node (SN) is a key site to study tumour-specific T ...
17 CitationsSource
#1Nayyer Iqbal (U of S: University of Saskatchewan)H-Index: 7
#2Kamal Haider (U of S: University of Saskatchewan)H-Index: 9
Last. Hadi Goubran (U of S: University of Saskatchewan)H-Index: 20
view all 7 authors...
Abstract Oncology services utilize about 15% of the blood transfusion resources in the USA. Red blood cell transfusion is performed immediately before, during or after major surgery to compensate for blood loss and hemodilution. However, a lack of evidence-based guidelines leads to variable transfusion practices among clinicians. The benefits of transfusing blood products are obvious in life-threatening low blood cell counts or bleeding, but it is becoming apparent that deliberate blood transfus...
7 CitationsSource
#1Hadi Goubran (U of S: University of Saskatchewan)H-Index: 20
#2David P. Sheridan (U of S: University of Saskatchewan)H-Index: 11
Last. Jerard SeghatchianH-Index: 27
view all 5 authors...
Abstract Blood and blood-component therapy triggers immunological reactions in recipients. Transfusion-related immunomodulation [TRIM] is an important complex biological immune reaction to transfusion culminating in immunosuppression. The mechanisms underlying TRIM include the presence of residual leukocytes and apoptotic cells, the transfusion of immunosuppressive cytokines either present in donor components or generated during blood processing, the transfer of metabolically active growth facto...
32 CitationsSource
#1Ali Zirakzadeh (KI: Karolinska Institutet)H-Index: 11
#2Johan Kinn (KI: Karolinska Institutet)H-Index: 4
Last. Ola Winqvist (KI: Karolinska Institutet)H-Index: 45
view all 17 authors...
Cancer is currently treated by a combination of therapies, including chemotherapy which is believed to suppress the immune system. Combination of immunotherapy and chemotherapy correlates with impr ...
16 CitationsSource
#1Juan P. Cata (University of Texas MD Anderson Cancer Center)H-Index: 32
#2Javier Lasala (University of Texas MD Anderson Cancer Center)H-Index: 9
Last. Jay B. Shah (University of Texas MD Anderson Cancer Center)H-Index: 22
view all 5 authors...
Background. Perioperative blood transfusions are associated with poor survival in patients with solid tumors including bladder cancer. Objective. To investigate the impact of perioperative blood transfusions on oncological outcomes after radical cystectomy. Design. Systematic review and meta-analysis. Setting and Participants. Adult patients who underwent radical cystectomy for bladder cancer. Intervention. Packed red blood cells transfusion during or after radical cystectomy for bladder cancer....
31 CitationsSource
#1R. VallionH-Index: 2
#2Francis BonnefoyH-Index: 11
Last. Sylvain PerrucheH-Index: 19
view all 7 authors...
Red blood cell (RBC) alloimmunization is a major immunologic risk of transfusion. However, RBC storage facilitates white blood cell (WBC) apoptosis and apoptotic cells have immunomodulatory properties. We investigated the behavior of WBCs, and apoptosis in particular, in RBC units during storage and then studied the impact of WBC apoptosis on the modulation of posttransfusion alloimmunization in RBC products stored short term. We used a mouse model of alloimmunization to transfused HEL-ovalbumin...
11 CitationsSource
#1Jin Hu (KI: Karolinska Institutet)H-Index: 6
#2Johan Kinn (KI: Karolinska Institutet)H-Index: 4
Last. Ola Winqvist (KI: Karolinska Institutet)H-Index: 45
view all 7 authors...
Recent studies indicate that chemotherapeutic agents may increase the anti-tumoral immune response. Based on the pivotal role of dendritic cells (DCs) in host tumour-specific immune responses, we i ...
36 CitationsSource
#1Robert RosenblattH-Index: 9
#2Amir Sherif (Karolinska University Hospital)H-Index: 26
Last. Per Malmström (Uppsala University Hospital)H-Index: 34
view all 7 authors...
Abstract Background Characterising responders to neoadjuvant chemotherapy (NAC) is important to minimise overtreatment and the unnecessary delay of definitive treatment of urothelial urinary bladder cancer. Objective To assess the effect of NAC on tumour downstaging and overall survival. Design, setting, and participants A total of 449 patients from the randomised prospective Nordic Cystectomy Trials 1 and 2 were analysed retrospectively. Eligible patients were defined as T2–T4aNXM0 preoperative...
159 CitationsSource
#1Emil Scosyrev (UR: University of Rochester)H-Index: 16
#2Deep TrivediH-Index: 3
Last. Edward M. MessingH-Index: 83
view all 3 authors...
Purpose of reviewWomen are generally less likely to develop bladder cancer compared with men; however, once they acquire this disease, they have a less favorable prognosis. In this review, we describe our current understanding of the relationship between sex and bladder cancer incidence and outcomes
26 CitationsSource
#1Oliver Karam (UdeM: Université de Montréal)H-Index: 19
#2Marisa TucciH-Index: 24
Last. Françoise Le DeistH-Index: 1
view all 8 authors...
BACKGROUND: The relationship between length of storage of red blood cell (RBC) units and biochemical changes has been well studied, but little is known about the progression of cellular immunomodulative properties in blood recipients. This study aims to quantify in vitro T-cell activation and cytokine release by white blood cells, after incubation with supernatants from leukoreduced RBCs. STUDY DESIGN AND METHODS: Whole blood cultures were incubated with supernatant from five leukoreduced RBC un...
47 CitationsSource
Cited By2
Newest
#1Boaz Wong (Ottawa Hospital Research Institute)H-Index: 1
#2Sameer S. Apte (Ottawa Hospital Research Institute)H-Index: 1
Last. Carolyn Nessim (Ottawa Hospital Research Institute)H-Index: 1
view all 9 authors...
Abstract (248 Words) Background Surgery for retroperitoneal soft tissue sarcoma (RPS) is technically challenging, often requiring perioperative red blood cell transfusion (PBT). In other cancers, controversy exists regarding the association of PBT and oncologic outcomes. No study has assessed this association in primary RPS, or identified factors associated with PBT. Methods Data was collected on all resected primary RPS between 2006 and 2020 at The Ottawa Hospital (Canada) and University Hospit...
1 CitationsSource
#1Yannic Volz (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Lennert Eismann (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Gerald Schulz (LMU: Ludwig Maximilian University of Munich)H-Index: 8
view all 8 authors...
Objective: To conduct a systematic review of whether blood transfusions may be associated with worse outcomes for patients with bladder cancer treated with radical cystectomy (RC), as there has bee...
1 CitationsSource