Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis
Abstract
Background and aims Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an important role in atherosclerosis. Methods and results ADAMTS7 knockdown in vascular endothelial cells (ECs) attenuated their...
Paper Details
Title
Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis
Published Date
Mar 1, 2020
Journal
Volume
296
Pages
11 - 17
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