Activin-driven fate determination is pivotal for liver progenitor cells to take over hepatocytic function in in ACLF

Liver progenitor cell (LPC) differentiation into mature hepatocytes determines survival and recovery of patients with acute-on-chronic liver failure (ACLF), who suffer from massive hepatic necrosis. Interestingly, even in irreversible ACLF, LPCs differentiate towards hepatocytes. However, these LPC-derived hepatocytes do not provide sufficient hepatocytic function, as required for systemic homeostasis. This study demonstrates a crucial role of...