Internal medicine

Azacitidine

Biology

Gene

Gene expression

Oncology

DNA methylation

Immunology

Clofarabine

NPM1

Chronic lymphocytic leukemia

Cytarabine

Leukemia

Myeloid leukemia

Alemtuzumab

Venetoclax

Transplantation

Chromosome

Cancer research

Karyotype

Genetics

Medicine

Blood

Adaptive resistance is often associated with TP53 abnormalities or kinase activation, particularly FLT3 internal tandem duplication. NPM1 mutation is associated with excellent survival prospects and durable molecular remission after venetoclax-based combination therapy.

Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML