The Clinical and Laboratory Standards Institute Subcommittee on Antimicrobial Susceptibility Testing: Background, Organization, Functions, and Processes

Published on Feb 24, 2020in Journal of Clinical Microbiology5.897
· DOI :10.1128/JCM.01864-19
Melvin P. Weinstein53
Estimated H-index: 53
(RU: Rutgers University),
James S. Lewis11
Estimated H-index: 11
(OHSU: Oregon Health & Science University)
The CLSI Subcommittee on Antimicrobial Susceptibility Testing is a volunteer-led, multidisciplinary consensus body that develops and publishes standards and guidelines (among other products) for antimicrobial susceptibility testing (AST) methods and results interpretation in the United States and internationally. The Subcommittee (SC) meets face-to-face twice yearly, and its working groups are active throughout the year via teleconferences. All meetings are open to the public. Participants include clinical microbiologists, infectious diseases pharmacists, and infectious diseases physicians representing the health care professions, government, and industry. Individuals who work for a company with a primary financial dependency on drug sales cannot serve as voting members, and well-defined conflict of interest polices are in place. In addition to developing and updating susceptibility breakpoints, the SC develops and validates new testing methods, provides guidance on how results should be interpreted and applied, sets quality control ranges, and educates users through seminars, symposia, and webinars. Based on its work, the SC publishes print and electronic standards and guidelines, including an annual update: Performance Standards for Antimicrobial Susceptibility Testing (M100). This commentary will describe the background, organization, functions, and operational processes of the AST SC.
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