Multiple risk factors for diabetes mellitus in patients with chronic pancreatitis: A multicentre study of 1117 cases

Published on Jan 17, 2020in United European gastroenterology journal3.549
· DOI :10.1177/2050640620901973
Søren Schou Olesen28
Estimated H-index: 28
(AAU: Aalborg University),
Jakob Lykke Poulsen15
Estimated H-index: 15
(AAU: Aalborg University)
+ 16 AuthorsAsbjørn Mohr Drewes78
Estimated H-index: 78
(AAU: Aalborg University)
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Abstract
BackgroundDiabetes mellitus is a common complication of chronic pancreatitis. It is traditionally considered to develop as a consequence of beta cell loss, but there might be additional factors. Re...
References27
Newest
#1Søren Schou Olesen (AAU: Aalborg University)H-Index: 28
view all 21 authors...
Abstract Background Pancreatic calcifications is a common finding in patients with chronic pancreatitis (CP), but the underlying pathophysiology is incompletely understood. Past studies for risk factors of calcifications have generally been focused on single parameters or limited by small sample sizes. The aim of this study was to explore several patient and disease characteristics and their associations with pancreatic calcifications in a large cohort of CP patients with diverse aetiological ri...
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#1Mark O. Goodarzi (Cedars-Sinai Medical Center)H-Index: 67
#2Tanvi Nagpal (University of Pittsburgh)H-Index: 1
Last. David C. WhitcombH-Index: 89
view all 36 authors...
Introduction:Diabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to
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#1Søren Schou Olesen (AAU: Aalborg University)H-Index: 28
#2Asbjørn Mohr Drewes (AAU: Aalborg University)H-Index: 78
Last. Camilla NøjgaardH-Index: 12
view all 4 authors...
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#1Sarah Jane Schwarzenberg (UMN: University of Minnesota)H-Index: 41
#2Aliye Uc (Boston Children's Hospital)H-Index: 27
Last. Mark E. LoweH-Index: 44
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ABSTRACTObjectives:The aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.Me
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OBJECTIVES:Chronic pancreatitis (CP) is characterized by several disease-related complications and multiple etiological risk factors. Past studies of associations between complications and risk factors have mostly been limited to single complications or highly focused on single etiologies. Using an
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#1Ayush Sharma (Mayo Clinic)H-Index: 11
#2Harika Kandlakunta (Mayo Clinic)H-Index: 2
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
view all 7 authors...
Background & Aims Of patients with new-onset diabetes (NOD; based on glycemic status) older than 50 years, approximately 1% are diagnosed with pancreatic cancer (PC) within 3 years. We aimed to develop and validate a model to determine risk of PC in patients with NOD. Methods We retrospectively collected data from 4 independent and nonoverlapping cohorts of patients (N = 1,561) with NOD (based on glycemic status; data collected at date of diagnosis and 12 months previously) in the Rochester Epid...
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#1Ayush Sharma (Mayo Clinic)H-Index: 11
#2Thomas C. Smyrk (Mayo Clinic)H-Index: 116
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
view all 5 authors...
Background & Aims It is unclear how long pancreatic ductal adenocarcinomas (PDACs) are present before diagnosis. Patients with PDAC usually develop hyperglycemia and diabetes before the tumor is identified. If early invasive PDACs are associated with hyperglycemia, the duration of hyperglycemia should associate with the time that they have had the tumor. Methods We collected data on patients with PDACs from medical databases in Olmsted County, Minnesota, from 2000 through 2015 and from the Mayo ...
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#1Anna L. Gloyn (University of Oxford)H-Index: 67
#2Daniel J. Drucker (Lunenfeld-Tanenbaum Research Institute)H-Index: 138
Summary The study of type 2 diabetes has been driven by advances in human genetics, epigenetics, biomarkers, mechanistic studies, and large clinical trials, enabling new insights into disease susceptibility, pathophysiology, progression, and development of complications. Simultaneously, several new drug classes with different mechanisms of action have been introduced over the past two decades, accompanied by data about cardiovascular safety and non-glycaemic outcomes. In this Review, we critical...
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#1Melena D. BellinH-Index: 41
#2David C. Whitcomb (University of Pittsburgh)H-Index: 89
Last. Dhiraj Yadav (University of Pittsburgh)H-Index: 52
view all 24 authors...
Patient and Disease Characteristics Associated With the Presence of Diabetes Mellitus in Adults With Chronic Pancreatitis in the United States
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Cited By8
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#1Phil A Hart (NIH: National Institutes of Health)
#2Dana K. Andersen (NIH: National Institutes of Health)H-Index: 21
Last. Mark O. Goodarzi (Cedars-Sinai Medical Center)H-Index: 67
view all 4 authors...
PURPOSE OF REVIEW Diabetes secondary to pancreatic diseases (i.e., acute pancreatitis, chronic pancreatitis, and pancreatic cancer) is increasingly studied, but remains challenging to distinguish from type 2 diabetes (T2DM). We review the clinical significance and potential biomarkers that may help differentiate these types of diabetes. RECENT FINDINGS Recent studies have identified several complications (including nonvascular) that occur more frequently in patients with diabetes secondary to ac...
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#1Mark O. Goodarzi (NIH: National Institutes of Health)
#2Maxim S. PetrovH-Index: 28
Last. Phil A. HartH-Index: 29
view all 4 authors...
PURPOSE OF REVIEW The purpose of this review is to delineate risk factors for the development of diabetes in patients with chronic pancreatitis. The natural history including progression to diabetes and complications that develop once diabetes occurs in chronic pancreatitis is also reviewed. RECENT FINDINGS Studies have found that predictors of diabetes in chronic pancreatitis include both risk factors for type 2 diabetes (e.g., obesity, genetic variants) as well as pancreas-specific factors (e....
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#1Søren Schou Olesen (AAU: Aalborg University)H-Index: 28
#2Rasmus Hagn-Meincke (AAU: Aalborg University)
Last. Jens Brøndum Frøkjær (AAU: Aalborg University)H-Index: 32
view all 5 authors...
Diabetes mellitus is a frequent complication of chronic pancreatitis (CP) and has traditionally been considered to develop as a consequence of pancreatic islet cell loss. However, additional mechan...
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Chronic pancreatitis (CP) is characterized by progressive inflammation and fibrosis of the pancreas that eventually leads to pancreatic exocrine and endocrine insufficiency. Diabetes in the background of CP is very difficult to manage due to high glycemic variability and concomitant malabsorption. Progressive beta cell loss leading to insulin deficiency is the cardinal mechanism underlying diabetes development in CP. Alpha cell dysfunction leading to deranged glucagon secretion has been describe...
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#1Jorge D. Machicado (Mayo Clinic)H-Index: 13
#2Georgios I. Papachristou (The Ohio State University Wexner Medical Center)H-Index: 49
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#1Mark O. Goodarzi (Cedars-Sinai Medical Center)H-Index: 67
#2Tanvi Nagpal (University of Pittsburgh)H-Index: 1
Last. David C. WhitcombH-Index: 89
view all 36 authors...
Introduction:Diabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to
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