Joint forces of direct, single particle, CE– and HPLC–inductively coupled plasma mass spectrometry techniques for the examination of gold nanoparticle accumulation, distribution and changes inside human cells

The intracellular localization and transformation of gold nanoparticles (AuNPs) are among the crucial aspects in future applications in cancer therapy. In the context of the study, inductively coupled plasma mass spectrometry (ICP-MS)-based techniques were effectively applied to reveal the fate of AuNPs internalized in cancerous MCF-7 cells. Direct ICP-MS was used to obtain quantitative information about the distribution rate of gold from the...