FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease that affects predominantly the right ventricle and is part of the spectrum of arrythmogenic cardiomyopathies (ACMs). ARVC is a genetic condition; however, a pathogenic gene variant is found in only half of patients. Objective Filamin C gene truncations ( FLNCtv ) have recently been identified in dilated cardiomyopathy with ventricular arrhythmia and...