PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

Volume: 77, Issue: 5, Pages: 1092 - 1106.e9
Published: Mar 1, 2020
Abstract
Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins is emerging as a promising therapeutic strategy. Despite intense efforts to rationally design degrader molecules that co-opt CRL4s, much about the organization and regulation of these ligases remains elusive. Here, we establish protein interaction kinetics and estimation of stoichiometries (PIKES) analysis, a systematic proteomic profiling platform that...
Paper Details
Title
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
Published Date
Mar 1, 2020
Volume
77
Issue
5
Pages
1092 - 1106.e9
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