PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
Abstract
Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins is emerging as a promising therapeutic strategy. Despite intense efforts to rationally design degrader molecules that co-opt CRL4s, much about the organization and regulation of these ligases remains elusive. Here, we establish protein interaction kinetics and estimation of stoichiometries (PIKES) analysis, a systematic proteomic profiling platform that...
Paper Details
Title
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
Published Date
Mar 1, 2020
Journal
Volume
77
Issue
5
Pages
1092 - 1106.e9
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