Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
Abstract
Female reproductive success critically depends on the size and quality of a finite ovarian reserve. Paradoxically, mammals eliminate up to 80% of the initial oocyte pool through the enigmatic process of fetal oocyte attrition (FOA). Here, we interrogate the striking correlation of FOA with retrotransposon LINE-1 (L1) expression in mice to understand how L1 activity influences FOA and its biological relevance. We report that L1 activity triggers...
Paper Details
Title
Maximizing the ovarian reserve in mice by evading LINE-1 genotoxicity
Published Date
Jan 16, 2020
Journal
Volume
11
Issue
1
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