Generalized pustular psoriasis

Psoriasis

Performance art

Dermatology

Erythroderma

Art history

Medicine

Journal of Investigative Dermatology

Generalized pustular psoriasis (GPP) represents a rare pustular disease manifesting as a multisystemic inflammation in a chronic or episodic course, sometimes as life-threatening incidents. Biallelic IL36RN mutations are known to be disease-causing or -contributing in 21–41% of patients with GPP (Hussain et al., 2015; Marrakchi et al., 2011; Mössner et al., 2018; Onoufriadis et al., 2011; Sugiura et al., 2013). IL-36 binds to the IL-36 receptor complex, thereby triggering the activation of mitogen-activated protein kinase and NF-κB, resulting in the production of proinflammatory cytokines.

Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis