Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice
Abstract
Parietal cells of the gastric mucosa contain a complex and extensive secretory membrane system that harbors gastric H+, K+-adenosine triphosphatase (ATPase), the enzyme primarily responsible for gastric lumen acidification. Here, we describe the characterization of mice deficient in the H+, K+-ATPase α subunit (Atp4a−/−) to determine the role of this protein in the biosynthesis of this membrane system and the biology of the gastric mucosa....
Paper Details
Title
Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice
Published Date
Feb 1, 2020
Journal
Volume
40
Issue
2
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