Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis
Abstract
The noncanonical Wnt ligand Wnt5a is found in high concentrations in ascites of women with ovarian cancer. In this study, we elucidated the role of Wnt5a in ovarian cancer metastasis. Wnt5a promoted ovarian tumor cell adhesion to peritoneal mesothelial cells as well as migration and invasion, leading to colonization of peritoneal explants. Host components of the ovarian tumor microenvironment, notably peritoneal mesothelial cells and visceral...
Paper Details
Title
Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis
Published Date
Mar 1, 2020
Journal
Volume
80
Issue
5
Pages
1156 - 1170
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Notes
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