Molecular interactions between Pluronic F127 and saponin in aqueous solution

Published on Feb 1, 2020in Colloid and Polymer Science1.931
· DOI :10.1007/S00396-019-04552-Z
Rosemaire S. S. de Oliveira1
Estimated H-index: 1
(UCSC: University of California, Santa Cruz),
Nélida Simona Marin Huachaca2
Estimated H-index: 2
(UCSC: University of California, Santa Cruz)
+ 3 AuthorsLuiz C. Salay10
Estimated H-index: 10
(UCSC: University of California, Santa Cruz)
Nanotechnology is important for the development of new materials capable to improve the development of novel drug delivery systems. Such systems may result in more efficient therapeutic effects with reduced toxicity and extended time in the organism and increase in bioavailability, biocompatibility, and solubility of drugs. Here it was investigated the interaction between the triblock copolymer Pluronic F127 (F127) and a natural bioactive amphiphilic saponin (SAP), extracted from Glycyrrhiza glabra roots, aiming to form micelle-like F127-SAP complexes in a pH 7.4 HEPES buffered aqueous solution, with potential nanobiotechnological applications. Differential scanning calorimetry (DSC), dynamic light scattering (DLS), and dynamic electrophoretic light scattering (DESL) were the techniques used in this investigation, at varied SAP concentrations below and above CMC at fixed 500 μM F127. The SAP-F127 molecular interactions were verified by changes in the critical micellar temperature (CMT) of F127 obtained from the DSC thermograms, while DLS and DELS data showed, respectively, the formation larger structures of the complexes relative to the single Pluronic micelles and zeta potential (ζ) values ranging from ca − 6.5 to − 9 mV, on varying the SAP concentration. Combined, these results indicate the formation of micelle-like complexes, with structure dependent on the SAP concentration, as highly promising agents in nanobiotechnology applications.
📖 Papers frequently viewed together
#1Luciana Sciascia (University of Palermo)H-Index: 14
#2Selene Casella (University of Liverpool)H-Index: 4
Last. Filippo Parisi (University of Palermo)H-Index: 29
view all 7 authors...
Abstract Green composites for environmental applications were successfully prepared by intercalation of the biosurfactant Quillaja saponin onto montmorillonite mineral clay on varying pH and surfactant/clay ratio. Equilibrium adsorption isotherms were constructed and the system was characterized by performing TGA and XRD analyses. The efficiency of the surfactant-modified clay in the removal of the organic content present in olive mill wastewaters (OMW) was evaluated by means of spectrophotometr...
#1Luiz C. Salay (UCSC: University of California, Santa Cruz)H-Index: 10
#2Elielma A. Prazeres (UCSC: University of California, Santa Cruz)H-Index: 1
Last. Eloi Feitosa (UNESP: Sao Paulo State University)H-Index: 26
view all 9 authors...
Triblock copolymers, such as Pluronic F127 (F127), are pharmaceutically important amphiphilic compounds that self-assemble in aqueous solution either as discrete or entangled micelles, depending on their concentration and temperature, which may function as drug delivery vehicle. Herein, we have synthesized the antimicrobial peptide tritrpticin (TRP3), a tryptophan (Trp)- and arginine (Arg)-rich peptide, sequence VRRFPWWWPFLRR, with a broad spectrum of action against bacteria and fungi, to invest...
#1Reza Hajimohammadi (BNUT: Babol Noshirvani University of Technology)H-Index: 3
#2Morteza Hosseini (BNUT: Babol Noshirvani University of Technology)H-Index: 47
Last. Ghasem D. Najafpour (BNUT: Babol Noshirvani University of Technology)H-Index: 41
view all 4 authors...
Saponins are the main group of phytogenic biosurfactants extracted from plants. One of the significant applications of these compounds is upgrading and viscosity reduction of heavy crude oil water in oil (W/O) emulsions. In this research, use of saponin extracted from Glycyrrhiza glabra was investigated for viscosity reduction of heavy crude oil and upgrading its API properties. The extracted saponin was characterized using Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) s...
#1Gergő Gyulai (ELTE: Eötvös Loránd University)H-Index: 11
#2Anna Magyar (ELTE: Eötvös Loránd University)H-Index: 16
Last. Sz. Bősze (ELTE: Eötvös Loránd University)H-Index: 3
view all 6 authors...
Biodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug delivery the end group derivative of Pluronics was synthe- sized in a straightforward way to obtain Pluronic-amines. The formation of functional amine groups was confirmed by flu- orescamine method and NMR a...
#1Ana Claudia Mendonça dos Santos (UFABC: Universidade Federal do ABC)H-Index: 1
#2Alessandra Cristina Santos Akkari (UFABC: Universidade Federal do ABC)H-Index: 5
Last. Daniele Ribeiro de AraujoH-Index: 29
view all 11 authors...
In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407–PL 188 hydrogels containing tramadol (TR) to analyze its potential treatment of acute pain. Drug–micelle interaction studies showed the forma...
#1Joseph H. Lorent (UCL: Université catholique de Louvain)H-Index: 14
#2Joëlle Quetin-Leclercq (UCL: Université catholique de Louvain)H-Index: 49
Last. Marie-Paule Mingeot-Leclercq (UCL: Université catholique de Louvain)H-Index: 49
view all 3 authors...
Saponins, amphiphiles of natural origin with numerous biological activities, are widely used in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective cytotoxic effects on cancer cells but the tendency of saponins to induce hemolysis limits their anticancer potential. This review focused on the effects of saponin activity on membranes and consequent implications for red blood and cancer cells. This activity seems to be strongly related to the amphiphilic character o...
Objective: A review article on Glycyrrhiza glabra, A plant which have lots of medicinal properties. So it may be known as plant for the future. The present article is an effort to highlight the role of a few major constituents of this plant, which have multifaceted pharmacological actions and could be used as a template for designing new herbal medicines. Plants have been one of the important sources of medicines since the beginning of human cultivation. There is a growing demand for plant based...
#1S. Honary (Mazandaran University of Medical Sciences)H-Index: 8
#2Foruhe Zahir (Mazandaran University of Medical Sciences)H-Index: 1
The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta poten...
#1Loredana E. NitaH-Index: 16
#2Aurica P. ChiriacH-Index: 17
Last. Bernhard A. Wolf (University of Mainz)H-Index: 30
view all 4 authors...
Abstract Pluronic F127/poly(aspartic acid) mixtures were investigated in dilute solutions by viscometry and dynamic light scattering. The two polymers were chosen due to well known applications in biomedical field, taking into account the final purpose (the use of the complex structure as drug delivery systems). The central item was to identify the possibility of complexation between the poly(carboxylic acid) and a non-ionic polymer and to investigate the conditions of the interpolymer complex f...
#1Amelia Torcello-Gómez (UGR: University of Granada)H-Index: 18
#2J. Maldonado-Valderrama (UGR: University of Granada)H-Index: 19
Last. Timothy J. FosterH-Index: 112
view all 4 authors...
Pluronics are being introduced in food research in order to delay lipid digestion, with the length of hydrophilic and hydrophobic chains playing an important role in the rate of such a process. Since bile salts play a crucial role in the lipid digestion process, the aim of this work is to analyze the interactions between Pluronic F127 or F68 and the bile salt NaTDC when the latter is added at physiological concentrations. These interactions are studied at the Pluronic-covered oil–water interface...
Cited By6
#1Ian M. TuckerH-Index: 24
#2A. BurleyH-Index: 3
Last. Robert J. Thomas (University of Oxford)H-Index: 83
view all 10 authors...
Abstract null null Saponins are plant based biosurfactants that are obtained from a wide variety of plant species. They are surface active glycosides with a hydrophobic group, which is commonly a triterpenoid or steroidal group, and saccharide hydrophilic units. Their structures are markedly different from conventional synthetic surfactants, and present interesting challenges in understanding their optimal packing in self-assembled structures such as micelles. Furthermore the wide variety of mol...
#1Ian M. TuckerH-Index: 24
#2A. BurleyH-Index: 3
Last. James Doutch (RAL: Rutherford Appleton Laboratory)H-Index: 21
view all 10 authors...
Abstract There is an increased interest in the use of natural surfactant as replacements for synthetic surfactants due to their biosustainable and biocompatible properties. A category of natural surfactants which are attracting much current interest is the triterpenoid saponins; surface active components found extensively in a wide range of plant species. A wide range of different saponin structures exist, depending upon the plant species they are extracted from; but regardless of the variation ...
#1Laura Earnden (U of G: University of Guelph)H-Index: 1
#2Alejandro G. Marangoni (U of G: University of Guelph)H-Index: 80
Last. Erica Pensini (U of G: University of Guelph)H-Index: 14
view all 5 authors...
Nonaqueous phase liquids (NAPL, e.g., hydrocarbons and chlorinated compounds) are common groundwater pollutants. Electrokinetic remediation of NAPLs uses electric fields to draw them toward electrodes and remove them from groundwater. The treatment requires NAPL mobility. Emulsification increases mobility, but at a risk for downstream receptors. We propose using alkaline aqueous solutions of zein and graphene nanoparticles (GNP) to form conductive materials, which could also act as barriers to c...
#1B. L. Pelegrini (CNRS: Centre national de la recherche scientifique)
#2F. M. B. Fernandes (CNRS: Centre national de la recherche scientifique)
view all 13 authors...
The development of Pickering emulsions as ecologically correct stabilized with bio-based material by substituting synthetic petroleum-derived tensoactives assumed a very attractive level, representing the current guideline of the global market for homecare industry, food and beverage applications. In this wor, cellulose nanocrystals (CNCs), a hierarchically advanced biomaterial, were produced to stabilize innovative emulsions formulated with western soapberry Sapindus saponaria L. oil (SO). Besi...
Saponins are bioactive compounds belonging to the secondary metabolism of plants widely used for their beneficial actions to human health. In this work the association of the saponin from Glycyrrhiza glabra with a matrix of multi-walled carbon nanotubes was promoted to obtain a composite material with improved functional characteristics. For this investigation, chemically modified electrodes (CME) based on carbon paste were developed. Firstly, a carbon paste electrode (CPE) modified with the add...
#1Natielle Cachoeira Dotivo (UCSC: University of California, Santa Cruz)H-Index: 2
#2Rachel Passos Rezende (UCSC: University of California, Santa Cruz)H-Index: 15
Last. João Carlos Teixeira Dias (UCSC: University of California, Santa Cruz)H-Index: 15
view all 11 authors...
Traditional therapy for malignant neoplasms involving surgical procedures, radiotherapy and chemotherapy aims to kill neoplastic cells, but also affects normal cells. Therefore, exogenous proteases are the target of studies in cancer therapy, as they have been shown to be effective in suppressing tumors and reducing metastases. Pluronic F127 (F127) is a copolymer of amphiphilic blocks that has shown significant potential for drug administration, as it is capable of incorporating hydrophobic drug...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.