Exploring Targeted Degradation Strategy for Oncogenic KRASG12C.
Abstract
Summary null null KRAS is the most frequently mutated oncogene found in pancreatic, colorectal, and lung cancers. Although it has been challenging to identify targeted therapies for cancers harboring KRAS mutations, KRASG12C can be targeted by small-molecule inhibitors that form covalent bonds with cysteine 12 (C12). Here, we designed a library of C12-directed covalent degrader molecules (PROTACs) and subjected them to a rigorous evaluation...
Paper Details
Title
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C.
Published Date
Jan 16, 2020
Journal
Volume
27
Issue
1
Pages
19
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