Catalysis

Electrochemiluminescence

Photochemistry

Chromatography

Reactive oxygen species

Biochemistry

Inorganic chemistry

Antioxidant capacity

Chemiluminescence

Organic chemistry

Oxygen

Trolox

Linear range

Antioxidant

Luminol

Chemistry

Detection limit

Angewandte Chemie International Edition

The traditional luminol-H2 O2 electrochemiluminescence (ECL) sensing platform suffers from self-decomposition of H2 O2 at room temperature, hampering its application for quantitative analysis. In this work, for the first time we employ iron single-atom catalysts (Fe-N-C SACs) as an advanced co-reactant accelerator to directly reduce the dissolved oxygen (O2 ) to reactive oxygen species (ROS). Owing to the unique electronic structure and catalytic activity of Fe-N-C SACs, large amounts of ROS are efficiently produced, which then react with the luminol anion radical and significantly amplify the luminol ECL emission. Under the optimum conditions, a Fe-N-C SACs-luminol ECL sensor for antioxidant capacity measurement was developed with a good linear range from 0.8 μm to 1.0 mm of Trolox.

Single‐Atom Iron Boosts Electrochemiluminescence