Pseudoguaianelactones A-C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2.

Published on Feb 4, 2020in Chemical Communications5.996
· DOI :10.1039/C9CC09159A
Qingfeng Ruan6
Estimated H-index: 6
(Guangzhou University of Chinese Medicine),
Shiqin Jiang4
Estimated H-index: 4
(Guangzhou University of Chinese Medicine)
+ 6 AuthorsZhongxiang Zhao13
Estimated H-index: 13
(Guangzhou University of Chinese Medicine)
Sources
Abstract
Pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5, 7, 7] ring system featuring a α-methylene-γ-lactone moiety, together with new pseudoguaianelactone C (3), were isolated from the roots of Lindera glauca. Pseudoguaianelactones A–C (1–3) inhibited NO production with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds suppressed significantly the production of proinflammatory mediator (TNF-α, IL-6, IL-1β and PGE2) and the enzyme expression (iNOS and COX-2) in protein levels.
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