BS55 Regulation of skeletal muscle stem cell function in a mouse model of experimental atherosclerosis and hyperlipidaemia

Introduction

Apolipoprotein E deficient (ApoE KO) mice are an established model of hyperlipidemia and atherosclerosis, which displays increased oxidative stress and triglyceride contents in the skeletal muscle. Experimental evidence suggests that ApoE KO mice have impaired regeneration after injury. Skeletal muscle stem cells are responsible for the regenerative capacity of skeletal muscle and undergo activation, proliferation and...