Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer
Abstract
Purpose Maytansine (DM1) is a potent anticancer drug and limited in clinical application due to its poor water solubility and toxic side effects. Zein is widely used in nano drug delivery systems due to its good biocompatibility. In this study, we prepared DM1-loaded zein nanoparticles (ZNPs) to achieve tumor targeting and reduce toxic side effects of DM1. Methods: ZNPs were prepared by phase separation and Box-Behnken design was used to...
Paper Details
Title
Zein nanoparticles as nontoxic delivery system for maytansine in the treatment of non-small cell lung cancer
Published Date
Dec 24, 2019
Journal
Volume
27
Issue
1
Pages
100 - 109
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