Telomere length and telomerase activity in osteoporosis and osteoarthritis.

Published on Dec 24, 2019in Experimental and Therapeutic Medicine1.785
· DOI :10.3892/ETM.2019.8370
Persefoni Fragkiadaki15
Estimated H-index: 15
(UoC: University of Crete),
Dragana Nikitovic33
Estimated H-index: 33
(UoC: University of Crete)
+ 7 AuthorsAristidis Tsatsakis68
Estimated H-index: 68
(UoC: University of Crete)
Osteoarthritis (OA) and osteoporosis (OP) are associated skeletal pathologies and have as a distinct feature the abnormal reconstruction of the subchondral bone. OA and OP have been characterized as age-related diseases and have been associated with telomere shortening and altered telomerase activity (TA). This review discusses the role of telomeres and telomerase in OA and OP pathologies and focuses on the usability of telomere length (TL) and the rate of telomere shortening as potential disease biomarkers. A number of studies have demonstrated that telomere shortening may contribute to OA and OP as an epigenetic factor. Therefore, it has been claimed that the measurement of TL of chondrocytes and/or peripheral blood cells may be an appropriate marker for the evaluation of the progression of these diseases. However, there is a need to be perform further studies with larger cohorts, with the aim of obtaining objective results and a better understanding of the association between TL, inflammation and aging, in order to provide further insight into the pathophysiology of degenerative joint diseases.
📖 Papers frequently viewed together
1 Citations
23 Citations
#1Ariana Hudita (UB: University of Bucharest)H-Index: 7
#2Bianca Galateanu (UB: University of Bucharest)H-Index: 16
Last. Andra BalanescuH-Index: 16
view all 11 authors...
ObjectiveCetylated fatty acids are a group of naturally occurring fats of plant and/or animal origin. Cetyl myristoleate, in particular, was initially involved in osteoarthritis related research as...
5 CitationsSource
#1Dimitris TsoukalasH-Index: 13
#2Persefoni Fragkiadaki (UoC: University of Crete)H-Index: 15
Last. Daniela CalinaH-Index: 25
view all 10 authors...
: Telomere length, a marker of cellular aging, decreases with age and it has been associated with aging‑related diseases. Environmental factors, including diet and lifestyle factors, affect the rate of telomere shortening which can be reversed by telomerase. Telomerase activation by natural molecules has been suggested to be an anti‑aging modulator that can play a role in the treatment of aging‑related diseases. This study aimed to investigate the effect of natural compounds on telomerase activi...
33 CitationsSource
#1Eleni Vasilopoulos (TU: Temple University)H-Index: 2
#2Persefoni Fragkiadaki (UoC: University of Crete)H-Index: 15
Last. Aristidis Tsatsakis (UoC: University of Crete)H-Index: 68
view all 14 authors...
: Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negat...
19 CitationsSource
#1Lailin Tao (HUST: Huazhong University of Science and Technology)H-Index: 2
#2Qin Huang (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Qi Wang (HUST: Huazhong University of Science and Technology)H-Index: 13
view all 9 authors...
Critically short telomeres indicate cellular senescence. Leukocyte telomere length (LTL) is regarded as an aging predictor. Osteoporosis is an age-related disease. The purpose of our study is to examine the association between LTL, and BMD and osteoporosis among an elderly Chinese population. A total of 1017 participants (584 postmenopausal women) with a mean age of 66.4 years were recruited from April 2016 to August 2017. Dual-energy X-ray absorptiometry was used for BMD measurement at skeleton...
3 CitationsSource
#1Marco Ponzetti (University of L'Aquila)H-Index: 8
#2Nadia Rucci (University of L'Aquila)H-Index: 41
The term osteoimmunology was coined many years ago to describe the research field that deals with the cross-regulation between bone cells and the immune system. As a matter of fact, many factors that are classically considered immune-related, such as interleukins (i.e. IL-6, -11,-17 and -23), tumor necrosis factor (TNF)-α, receptor-activator of nuclear factor kappa B (RANK) and its ligand (RANKL), nuclear factor of activated t-cell, cytoplasmatic-1 (NFATc1) and others have all been found to be c...
53 CitationsSource
#1Aristidis Tsatsakis (UoC: University of Crete)H-Index: 68
#2Dimitrios Tsoukalas (UoC: University of Crete)H-Index: 6
Last. Athanasios Alegakis (UoC: University of Crete)H-Index: 25
view all 9 authors...
Background: Telomere length (TL) is causally related to aging and several age-related diseases. Specifically, the abundance of short telomeres and the rate of telomere shortening are strong determinants of cell homeostasis. Thus, tools for analyzing and manipulating TL data can vastly improve research focused on aging. Aim: In this study, we developed a semi-automated worksheet, BIOTEL, to generate individual and group TL statistics and provide a crude estimation of biological age. Results: Data...
10 CitationsSource
#1Mingcai ZhangH-Index: 9
#2Justin L ThelemanH-Index: 1
Last. Jinxi WangH-Index: 24
view all 4 authors...
: Aging is a progressive and complicated bioprocess with overall decline in physiological function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older populations. Since the prevalence of OA increases with age and breakdown of articular cartilage is its major hallmark, OA has long been thought of as "wear and tear" of joint cartilage. Nevertheless, recent studies have revealed that changes in the chondrocyte function and matrix components may reduce the material proper...
18 CitationsSource
#1Timothy E. McAlindon (Tufts Medical Center)H-Index: 72
#2Mary B. Roberts (Brown University)H-Index: 26
Last. Charles B. Eaton (Brown University)H-Index: 80
view all 11 authors...
Summary Objective To evaluate the relationship of telomere length to the prevalence and incidence of hand osteoarthritis in a longitudinal cohort. Design We conducted a cross-sectional and longitudinal analysis of data from a subset of participants in the Osteoarthritis Initiative (OAI) recruited between February 2004 and May 2006. 274 individuals were eligible for the study based on availability of both baseline and 48-month hand radiographs and peripheral blood leucocyte telomere length data. ...
10 CitationsSource
#1Esra Gozde Kosebent (Akdeniz University)H-Index: 3
#2Fatma Uysal (Ankara University)H-Index: 7
Last. Saffet Ozturk (Akdeniz University)H-Index: 14
view all 3 authors...
: Telomeres are repetitive non-coding DNA sequences located at the ends of chromosomes in eukaryotic cells. Their most important function is to protect chromosome ends from being recognized as DNA damage. They are also implicated in meiosis and synapse formation. The length of telomeres inevitably shortens at the end of each round of DNA replication and, also, as a consequence of the exposure to oxidative stress and/or genotoxic agents. The enzyme telomerase contributes to telomere lengthening. ...
16 CitationsSource
#1Yongjie YuH-Index: 3
#2Limin ZhouH-Index: 1
Last. Yuyu LiuH-Index: 8
view all 4 authors...
: Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge. An increasing body of evidence has indicated that CAG has a wide spectrum of pharmacological functions, which are attracting attention in the research community. The aim of the present review paper was to review and elucidate the advanced study of CAG. The focus was on advanced studies of CAG in English and Chinese databases; the literature ...
20 CitationsSource
Cited By14
#1Hans-Jürgen GruberH-Index: 14
Last. Markus HerrmannH-Index: 7
view all 4 authors...
Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-dimensional structure, they protect the coding DNA and ensure appropriate separation of chromosomes. Aging is characterized by a progressive shortening of telomeres, which compromises their structure and function. Because of their protective function for genomic DNA, telomeres appear to play an important role in the development and progression of many age-related diseases, such as cardiovascular disease (CVD), malign...
#1E. N. Dudinskaya (RSMU: Russian National Research Medical University)H-Index: 5
#2Olga N. Tkacheva (RSMU: Russian National Research Medical University)H-Index: 8
Last. Larina Vn (RSMU: Russian National Research Medical University)H-Index: 4
view all 8 authors...
To compare the effect of 12 months of treatment with moxonidine or bisoprolol on telomerase activity (TA) and parameters characterizing the arterial wall state in postmenopausal women with arterial hypertension (AH) and osteopenia. An open-label randomized study with 114 postmenopausal women with hypertension and osteopenia; pulse wave velocity (PWV), intima-media thickness (IMT), and TA were analyzed initially and after 12 months of therapy with moxonidine (n = 57) or bisoprolol (n = 57). Both ...
#1Guojun Wei (Ha Tai: Xiamen University)
#2Zhibing Peng (HMU: Harbin Medical University)
Last. Gang An (HMU: Harbin Medical University)H-Index: 4
view all 10 authors...
Sensitive and reliable analysis of telomerase activity is important for clinical diagnosis, therapy, and prognosis of osteosarcoma. Telomerase activity is a complicated concept including both the amount of active telomerases and the length of the telomerases extension product. Still, few of the strategies formerly proposed distinguish the two aspects of telomerase activity. Herein, we propose a novel CRISPR-Cas12a-based fluorescent sensing platform that can output signals of both the amounts of ...
#1Kaimin Gao (Ha Tai: Xiamen University)H-Index: 2
#2Yingxing Zhou (Ha Tai: Xiamen University)H-Index: 4
Last. Xiaomei Yan (Ha Tai: Xiamen University)H-Index: 29
view all 10 authors...
Telomere length (TL) is a highly relevant biomarker for age-associated diseases and cancer, yet its clinical applications have been hindered by the inability of existing methods to rapidly measure the TL distribution and the percentage of chromosomes with critically short telomeres (CSTs, < 3 kb). Herein, we report the development of a high-throughput method to measure TL at the single-chromosome level. Metaphase chromosomes are isolated, hybridized with the Alexa Fluor 488-labeled telomeric pep...
#1Dawei Cai (Nanjing Medical University)H-Index: 3
#2Huyong Yan (University of South China)
Last. Jian Qin (Nanjing Medical University)H-Index: 3
view all 7 authors...
Osteoarthritis (OA) is a common joint disorder characterized by progressive articular cartilage degeneration and destruction and results in gradual disability among middle-aged and elderly patients. Our previous study demonstrated that depletion of nuclear factor erythroid 2-related factor 2 (Nrf2) exacerbated cartilage erosion in an OA model and that activation of the Nrf2 pathway could counter this process. As a downstream target of Nrf2, heme oxygenase (HO) degrades heme to free iron, biliver...
Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common feature of age-related diseases. Therefore, telomere length (TL) has been recognized for a long time as one of the best biomarkers of aging. Recent research findings, however, indicate that TL per se can only allow a rough estimate of aging rate and can hardly be regarded as a clinically important risk marker for age-related pathologies and mor...
12 CitationsSource
#1Tina Levstek (University of Ljubljana)H-Index: 2
#2Sara Redenšek (University of Ljubljana)H-Index: 5
Last. Katarina Trebušak Podkrajšek (University of Ljubljana)H-Index: 15
view all 5 authors...
Telomeres, which are repetitive sequences that cap the end of the chromosomes, shorten with each cell division. Besides cellular aging, there are several other factors that influence telomere length (TL), in particular, oxidative stress and inflammation, which play an important role in the pathogenesis of neurodegenerative brain diseases including Parkinson's disease (PD). So far, the majority of studies have not demonstrated a significant difference in TL between PD patients and healthy individ...
#1Elisavet RenieriH-Index: 11
#2Elena VakonakiH-Index: 14
Last. Aristidis TsatsakisH-Index: 68
view all 5 authors...
#1Manju Mohan (University of Madras)H-Index: 1
#2Sridhar Muthusami (Karpagam University)H-Index: 9
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
view all 6 authors...
Abstract Cellular senescence is a hallmark of aging that is characterized by irreversible cell cycle arrest in response to various stress stimuli. It is a normal physiological event, which plays essential role in development, prevention of cancer, wound healing process, etc. Nevertheless, accumulation of senescent cells is the trigger and forms the basis of aging of a tissue/organ and, thus, the organismal aging. During aging, cells display a senescence-associated secretory phenotype (SASP) that...