doi.org/10.1016/j.semcdb.2019.11.013
Review paper

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

Kenneth W. Finnson
1
,
Yasser H Almadani
1
,
Anie Philip
26
Seminars in Cell and Developmental Biology6.20
Volume: 101, Pages: 115 - 122
Published: May 1, 2020
Abstract
Transforming growth factor (TGF)-β uses several intracellular signaling pathways besides canonical ALK5-Smad2/3 signaling to regulate a diverse array of cellular functions. Several of these so-called non-canonical (non-Smad2/3) pathways have been implicated in the pathogenesis of fibrosis and may therefore represent targets for therapeutic intervention. This review summarizes our current knowledge on the mechanisms of non-canonical TGF-β...
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Paper Details
Title
Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets
DOI
doi.org/10.1016/j.semcdb.2019.11.013
Published Date
May 1, 2020
Journal
Seminars in Cell and Developmental Biology
Volume
101
Pages
115 - 122
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