Understanding genetic determinants of resistance to immune checkpoint blockers
Abstract
The advent of immune checkpoint blockers (ICB) has revolutionized patient outcome in many tumor types. However, only a minority of patients truly benefits from these therapies and displays a durable and robust anti-tumor response that translates into improved outcome. Thorough mechanistic preclinical studies and comprehensive investigations performed in tumor biopsies of patients treated with ICB have unveiled multiple resistance mechanisms...
Paper Details
Title
Understanding genetic determinants of resistance to immune checkpoint blockers
Published Date
Oct 1, 2020
Journal
Volume
65
Pages
123 - 139
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Notes
History