p120-catenin-dependent collective brain infiltration by glioma cell networks
Abstract
Diffuse brain infiltration by glioma cells causes detrimental disease progression, but its multicellular coordination is poorly understood. We show here that glioma cells infiltrate the brain collectively as multicellular networks. Contacts between moving glioma cells are adaptive epithelial-like or filamentous junctions stabilized by N-cadherin, β-catenin and p120-catenin, which undergo kinetic turnover, transmit intercellular calcium...
Paper Details
Title
p120-catenin-dependent collective brain infiltration by glioma cell networks
Published Date
Jan 1, 2020
Journal
Volume
22
Issue
1
Pages
97 - 107
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