Lactoferrin improves cognitive function and attenuates brain senescence in aged mice

Lactoferrin (LF) has been shown to be effective in attenuating some aging-related changes, although its potential in alleviating aging-related cognitive decline remains to be clarified. In this study, we evaluated the effects of LF (2000 mg/kg/day for 3 months) on the cognitive ability of 16-month-old C57/BL6J mice. Spatial cognition was improved in aged mice after LF administration, with more pyramidal cells detected in the hippocampi, and more...