Carbohydrate metabolism

Enzyme

Glycolysis

Glucose 6-phosphate

Hexokinase

Biology

Cancer

Function (biology)

Chemistry

Cell growth

Metabolism

Cell biology

Genetics

Biochemistry

Intracellular

Cancer cell

International Journal of Molecular Sciences

The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death. In addition to glycolysis inhibition, other molecular processes are also affected by 2-DG. Attempts to improve 2-DG’s drug-like properties, its role as a potential adjuvant for other chemotherapeutics, and novel 2-DG analogs as promising new anticancer agents are discussed in this review.

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents