Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9
Abstract
The concept of triggered drug release offers a possibility to overcome the toxic side effects of chemotherapeutics in cancer treatment by reducing systemic exposure to the active drug. In the present work, the concept foresees the use of the extracellular enzyme MMP9 as an enzymatic trigger for drug release in the proximity of tumor cells. Methods: A paclitaxel-hemisuccinate-peptide conjugate as a building block for self-assembling nanoparticles...
Paper Details
Title
Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9
Published Date
Jan 2, 2020
Journal
Volume
31
Issue
3
Pages
781 - 793
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