The emerging role of SPOP protein in tumorigenesis and cancer therapy

Volume: 19, Issue: 1
Published: Jan 4, 2020
Abstract
The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited...
Paper Details
Title
The emerging role of SPOP protein in tumorigenesis and cancer therapy
Published Date
Jan 4, 2020
Volume
19
Issue
1
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