Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
Abstract
Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate composed of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. In a phase 1 dose-finding study, a majority of the patients with advanced HER2-positive breast cancer had a response to trastuzumab deruxtecan (median response duration, 20.7 months). The efficacy of trastuzumab deruxtecan in...
Paper Details
Title
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
Published Date
Feb 13, 2020
Volume
382
Issue
7
Pages
610 - 621
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