Tumour mutational burden: primary versus metastatic tissue creates systematic bias

Volume: 4, Pages: 8 - 14
Published: Dec 1, 2019
Abstract
Tumour mutational burden (TMB) has emerged as a reproducible biomarker to predict immunotherapy response across multiple cancer types. However, a key aspect of TMB measurement that is often overlooked is the source of tissue sample used, which creates a potential for systematic bias. The predominant source is either primary or metastatic tumour tissue. Primary tumours are more heterogeneous and reflect a longer period of tumour evolution,...
Paper Details
Title
Tumour mutational burden: primary versus metastatic tissue creates systematic bias
Published Date
Dec 1, 2019
Journal
Volume
4
Pages
8 - 14
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.