7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway
Volume: 72, Issue: 3, Pages: 385 - 395
Published: Dec 22, 2019
Abstract
Objectives Neuroprotective potential of 7-methoxyflavanone (7MF) and its underlying mechanism was investigated. Methods Inhibitory effects of 7MF on microglial activation and neuroinflammation were evaluated by employment of lipopolysaccharide (LPS)-induced BV2 microglial cells. Changes in expression of genes and proteins of interest were investigated by RT-qPCR analysis and Western blot analysis. Inhibitory effects of 7MF on microglial...
Paper Details
Title
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway
Published Date
Dec 22, 2019
Volume
72
Issue
3
Pages
385 - 395
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