Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis
Abstract
Gallic acid (3,4,5-trihydroxybenzoic acid, GA), a phenolic acid, is ubiquitous in almost all parts of the plant. In the present study, a neuroinflammatory rat model using intranigral infusion of lipopolysaccharides (LPS, 4 μg/μL) was employed to study the neuroprotective effect of GA which was orally administered daily. Compared with the vehicle-treated rats, systemic administration of GA (100 mg/kg) significantly attenuated LPS-induced...
Paper Details
Title
Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis
Published Date
Dec 12, 2019
Journal
Volume
57
Issue
1
Pages
96 - 104
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