Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions.

Published on Mar 1, 2020in Addiction Biology4.121
· DOI :10.1111/ADB.12866
Andreas Heinz97
Estimated H-index: 97
Falk Kiefer47
Estimated H-index: 47
(Heidelberg University)
+ 41 AuthorsRainer Spanagel79
Estimated H-index: 79
(Heidelberg University)
One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.
📖 Papers frequently viewed together
11 Citations
15 Citations
295 Citations
#1Andreas Heinz (Charité)H-Index: 97
#2Anne Beck (Charité)H-Index: 26
Last. Shuyan Liu (Charité)H-Index: 6
view all 6 authors...
Individuals with substance use disorders (SUDs) have to cope with drug-related cues and contexts which can affect instrumental drug seeking, as shown with Pavlovian-to-instrumental transfer (PIT) tasks among humans and animals. Our review addresses two potential mechanisms that may contribute to habitual or even compulsive drug seeking and taking. One mechanism is represented by Pavlovian and PIT effects on drug intake. The other is a shift from goal-directed to habitual drug intake, which can b...
11 CitationsSource
#1Daniel Durstewitz (Heidelberg University)H-Index: 28
#2Georgia Koppe (Heidelberg University)H-Index: 13
Last. Andreas Meyer-Lindenberg (Heidelberg University)H-Index: 94
view all 3 authors...
Machine and deep learning methods, today’s core of artificial intelligence, have been applied with increasing success and impact in many commercial and research settings. They are powerful tools for large scale data analysis, prediction and classification, especially in very data-rich environments (“big data”), and have started to find their way into medical applications. Here we will first give an overview of machine learning methods, with a focus on deep and recurrent neural networks, their re...
55 CitationsSource
: Los modelos animales en investigacion psiquiatrica han sido criticados en los ultimos anos por su limitado valor para ser trasladados a la situacion clinica. Las fallas en los ensayos clinicos a menudo han sido atribuidas a la falta de poder predictivo de los modelos animales preclinicos. En este articulo se argumenta que los modelos animales de ingesta voluntaria de drogas—bajo condiciones operantes y no operantes—y los modelos de adicciones basados en el Manual Diagnostico y Estadistico de l...
67 CitationsSource
#1Jerome C. Foo (UTokyo: University of Tokyo)H-Index: 7
#2Hamid R. Noori (MPG: Max Planck Society)H-Index: 18
Last. Yoshiharu Yamamoto (UTokyo: University of Tokyo)H-Index: 46
view all 9 authors...
The theory of critical transitions in complex systems (ecosystems, climate, etc.), and especially its ability to predict abrupt changes by early-warning signals based on analysis of fluctuations cl...
8 CitationsSource
#1Martina Kirsch (Heidelberg University)H-Index: 9
#2Isabella Gruber (Heidelberg University)H-Index: 1
Last. Peter Kirsch (Heidelberg University)H-Index: 55
view all 5 authors...
It has been shown that in alcoholic patients, alcohol-related cues produce increased activation of reward-related brain regions like the ventral striatum (VS), which has been proposed as neurobiological basis of craving. Modulating this activation might be a promising option in the treatment of alcohol addiction. One approach might be real-time functional magnetic resonance imaging neurofeedback (rtfMRI NF). This study was set up to implement and evaluate a rtfMRI approach in a group of non-addi...
54 CitationsSource
#1Tara Rezapour (Tehran University of Medical Sciences)H-Index: 5
#2Elise E. DeVito (Yale University)H-Index: 26
Last. Hamed Ekhtiari (Tehran University of Medical Sciences)H-Index: 20
view all 4 authors...
Abstract Addiction, as a brain disorder, can be defined with two distinct but interacting components: drug dependency and neurocognitive deficits. Most of the therapeutic interventions in addiction medicine, including pharmacological or psychosocial therapies, that are in clinical use have been mainly focused on directly addressing addictive behaviors, especially drug use and urges to use drugs. In the field of addiction treatment, it is often presumed that drug users’ neurocognitive deficits wi...
32 CitationsSource
#1Thomas E. Gladwin (UvA: University of Amsterdam)H-Index: 26
#2Corinde E. Wiers (Charité)H-Index: 20
Last. Reinout W. Wiers (UvA: University of Amsterdam)H-Index: 70
view all 3 authors...
Cognitive retraining or cognitive bias modification (CBM) involves having subjects repeatedly perform a computerized task designed to reduce the impact of automatic processes that lead to harmful behavior. We first discuss the theory underlying CBM and provide a brief overview of important research progress in its application to addiction. We then focus on cognitive- and neural-mediating mechanisms. We consider recent criticism of both CBM and its theoretical foundations. Evaluations of CBM coul...
27 CitationsSource
#1Fuschia Serre (University of Bordeaux)H-Index: 13
#2Mélina FatséasH-Index: 23
Last. Marc AuriacombeH-Index: 32
view all 4 authors...
Abstract Background Craving is viewed as a major determinant of relapse in persons with substance addiction, but this association remains poorly understood due to its time-limited nature and the biases associated with retrospective reporting. Ecological momentary assessment (EMA) offers new opportunities to examine both craving and substance use with strong ecological validity by collecting real-time data in daily life. This review examined all published studies using EMA to: (1) assess the link...
126 CitationsSource
#1Marcus W. Meinhardt (Heidelberg University)H-Index: 8
#2Wolfgang H. Sommer (Heidelberg University)H-Index: 44
Rational development of novel therapeutic strategies for alcoholism requires understanding of its underlying neurobiology and pathophysiology. Obtaining this knowledge largely relies on animal studies. Thus, choosing the appropriate animal model is one of the most critical steps in pre-clinical medication development. Among the range of animal models that have been used to investigate excessive alcohol consumption in rodents, the postdependent model stands out. It was specifically developed to t...
54 CitationsSource
#1Harriet R. Brown (University of Oxford)H-Index: 15
#2Peter Zeidman (University of Oxford)H-Index: 28
Last. Raymond J. Dolan (University of Oxford)H-Index: 180
view all 7 authors...
By 2015, there will be an estimated two billion smartphone users worldwide. This technology presents exciting opportunities for cognitive science as a medium for rapid, large-scale experimentation and data collection. At present, cost and logistics limit most study populations to small samples, restricting the experimental questions that can be addressed. In this study we investigated whether the mass collection of experimental data using smartphone technology is valid, given the variability of ...
57 CitationsSource
Cited By38
#1Veronika Pohořalá (Heidelberg University)
#2Thomas Enkel (Heidelberg University)H-Index: 8
Last. Rick E. Bernardi (Heidelberg University)H-Index: 10
view all 5 authors...
Rationale In classical conditioning, sign-tracking reflects behavior directed toward a conditioned stimulus (CS) in expectation of a reward (unconditioned stimulus, US); in contrast, goal-tracking describes behavior directed toward the location of delivery of a US. As cues previously paired with drugs of abuse promote drug-seeking and drug-taking behavior in both animals and humans and thus contribute to the severity of substance abuse, sign-tracking may represent a maladaptive cue-focused behav...
#1Bastian Schiller (University of Freiburg)H-Index: 7
#2Markus Heinrichs (University of Freiburg)H-Index: 62
Last. Ann-Kathrin Stock (TUD: Dresden University of Technology)H-Index: 22
view all 4 authors...
This study aimed to provide a currently missing link between general intoxication-induced changes in overall brain activity and the multiple cognitive control deficits typically observed during acute alcohol intoxication. For that purpose, we analyzed the effects of acute alcohol intoxication (1.1‰) on the four archetypal electroencephalography (EEG) resting networks (i.e., microstates A-D) and their temporal dynamics (e.g., coverage and transitions from one microstate to another), as well as on...
#1Shoupeng Wei (Heidelberg University)H-Index: 1
#2Sarah Hertle (Heidelberg University)H-Index: 1
Last. Ainhoa Bilbao (Heidelberg University)H-Index: 31
view all 4 authors...
Abstract Glutamatergic input via NMDA and AMPA receptors within the mesolimbic dopamine (DA) pathway plays a critical role in the development of addictive behavior and relapse toward drugs of abuse. Although well-established for drugs of abuse, it is not clear whether glutamate receptors within the mesolimbic system are involved in mediating chronic consumption and relapse following abstinence from a non-drug reward. Here, we evaluated the contribution of mesolimbic glutamate receptors in mediat...
Null hypothesis significance testing is the major statistical procedure in the field of fMRI, but provides only a rather limited picture of the effects in a data set. When sample size and power is low relying only on strict significance testing may lead to a host of false negative findings. In contrast, with very large data sets virtually every voxel might become significant. It is thus desirable to complement significance testing with procedures like inferiority and equivalence tests that allow...
#1Mehrdad Hasanpour (MPG: Max Planck Society)
#2Ekaterina Mitricheva (CAS: Chinese Academy of Sciences)
Last. Hamid R. Noori (CAS: Chinese Academy of Sciences)H-Index: 18
view all 4 authors...
Summary Rats have been used as animal models for human diseases for more than a century, yet a systematic understanding of basal biobehavioral phenotypes of laboratory rats is still missing. In this study, we utilize wireless tracking technology and videography, collect and analyze more than 130 billion data points to fill this gap, and characterize the evolution of behavior and physiology of group-housed male and female rats (n = 114) of the most commonly used strains (Lister Hooded, Long-Evans...
#1Damian Karl (Heidelberg University)H-Index: 2
#2J. Malte Bumb (Heidelberg University)H-Index: 7
Last. Sabine Vollstädt-Klein (Heidelberg University)H-Index: 25
view all 9 authors...
Rationale Alcohol use disorder is a common and devastating mental illness for which satisfactory treatments are still lacking. Nalmefene, as an opioid receptor modulator, could pharmacologically support the reduction of drinking by reducing the (anticipated) rewarding effects of alcohol and expanding the range of treatment options. It has been hypothesized that nalmefene acts via an indirect modulation of the mesolimbic reward system. So far, only a few imaging findings on the neuronal response ...
#1Vicente Pallarés (Polytechnic University of Valencia)
#1Vicente Pallarés (Universidad Miguel Hernández de Elche)H-Index: 12
Last. Petri Hyytiä (UH: University of Helsinki)H-Index: 35
view all 10 authors...
#1Maëlle Cm Gueguen (RU: Rutgers University)
#2Emma M Schweitzer (RU: Rutgers University)
Last. Anna B. Konova (RU: Rutgers University)H-Index: 13
view all 3 authors...
#1Michael Widder (FAU: University of Erlangen-Nuremberg)
#2Luisa Mierzwa (FAU: University of Erlangen-Nuremberg)
Last. Bernd Lenz (FAU: University of Erlangen-Nuremberg)H-Index: 21
view all 9 authors...
Alcohol consumption during pregnancy may lead to permanent damage in the offspring, including fetal alcohol spectrum disorders (FASD), which have an estimated prevalence of 1-8% worldwide. In adulthood, diagnosing FASD is time-consuming and costly. This study aimed to evaluate the discriminatory power of a German screening instrument for FASD in adults-the biographic screening interview (BSI-FASD). In an open-label comparative cohort study wherein a one-time survey was administered per participa...