Wound dressings functionalized with silver nanoparticles: promises and pitfalls

Published on Jan 30, 2020in Nanoscale6.895
· DOI :10.1039/C9NR08234D
Katayoon Kalantari16
Estimated H-index: 16
(NU: Northeastern University),
Ebrahim Mostafavi14
Estimated H-index: 14
(NU: Northeastern University)
+ 4 AuthorsThomas J. Webster104
Estimated H-index: 104
(NU: Northeastern University)
Infections are the main reason most people die from burns and diabetic wounds. The clinical challenge for treating wound infections through traditional antibiotics has been growing steadily and has now reached a critical status requiring a paradigm shift for improved chronic wound care. The USA Centers for Disease Control have predicted more deaths from antimicrobial-resistant bacteria than all types of cancers combined by 2050. Thus, the development of new wound dressing materials that do not rely on antibiotics is of paramount importance. Currently, incorporating nanoparticles into scaffolds represents a new concept of ‘nanoparticle dressing' which has gained considerable attraction for wound healing. Silver nanoparticles (Ag-NPs) have been categorized as metal-based nanoparticles and are intriguing materials for wound healing because of their excellent antimicrobial properties. Ag-NPs embedded in wound dressing polymers promote wound healing and control microorganism growth. However, there have been several recent disadvantages of using Ag-NP used to fight infections, like bacteria resistance. This review highlights the therapeutic approaches of using wound dressings functionalized with Ag-NPs and their potential role to revolutionize wound healing. Moreover, the physiology of skin and wounds are discussed to place the use of Ag-NPs in wound care into perspective.
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