Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain
Abstract
The transient receptor potential akyrin type-1 (TRPA1) is a non-selective cation channel playing a pivotal role in pain sensation and neurogenic inflammation. TRPA1 channels expressed in the central nervous system (CNS) have a critical role in the modulation of cortical spreading depression (CSD), which is a key pathophysiological basis of migraine pain. ADM_09 is a recently developed lipoic acid-based TRPA1 antagonist that is able to revert...
Paper Details
Title
Niosomal Formulation of a Lipoyl-Carnosine Derivative Targeting TRPA1 Channels in Brain
Published Date
Dec 10, 2019
Journal
Volume
11
Issue
12
Pages
669 - 669
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