TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Volume: 77, Issue: 11, Pages: 2103 - 2123
Published: Dec 10, 2019
Abstract
Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal transition (EMT) is the process in which cells lose epithelial integrity and become motile, a critical step for cancer cell invasion, drug resistance and immune evasion. The transforming growth factor-β (TGFβ) signaling pathway is a major driver of EMT. Increasing evidence demonstrates that metabolic reprogramming is a hallmark of cancer and extensive...
Paper Details
Title
TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Published Date
Dec 10, 2019
Volume
77
Issue
11
Pages
2103 - 2123
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