Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice

Volume: 50, Issue: 4, Pages: 515 - 524
Published: Jan 14, 2020
Abstract
The transcription factor Nrf2 regulates oxidative stress responses. However, the specific function of Nrf2 in Tregs, the central regulators of immune homeostasis, is unclear. Here, we report an unexpected but important role of Nrf2 in Tregs. Nrf2 expression driven by Foxp3 specific deletion of Keap1 resulted in an autoinflammatory phenotype with enhanced effector T cell activation and immune cell infiltrates in the lung. While early postnatal...
Paper Details
Title
Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice
Published Date
Jan 14, 2020
Volume
50
Issue
4
Pages
515 - 524
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