Low serum estradiol levels are related to Mycobacterium avium complex lung disease: a cross-sectional study

Published on Dec 16, 2019in BMC Infectious Diseases3.09
路 DOI :10.1186/S12879-019-4668-X
Yoshifumi Uwamino10
Estimated H-index: 10
(Keio: Keio University),
Tomoyasu Nishimura16
Estimated H-index: 16
(Keio: Keio University)
+ 9 AuthorsNaoki Hasegawa33
Estimated H-index: 33
(Keio: Keio University)
Sources
Abstract
Background The risk factors for Mycobacterium avium complex lung disease (MAC-LD) are not well known. We hypothesized that low serum estradiol (E2) levels are related to MAC-LD as most patients with MAC-LD are postmenopausal women.
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References16
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#1Sally B Coburn (HHS: United States Department of Health and Human Services)H-Index: 10
#2Frank Z. Stanczyk (SC: University of Southern California)H-Index: 105
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Purpose The comparability between serum, plasma, and urinary measurements of estrogen metabolites via liquid chromatography鈥搕andem mass spectrometry (LC鈥揗S/MS) has not been largely explored, and it is unclear if urinary LC鈥揗S/MS measurements are suitable surrogates of circulating levels.
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#1Tomoyasu Nishimura (Keio: Keio University)H-Index: 16
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Mycobacterium avium complex (MAC) pulmonary disease is prevalent in middle-aged to elderly women with a thin body habitus. By comparing the rate of serologically diagnosed asymptomatic MAC infection and body mass index among 1033 healthy subjects, we find that middle-aged to elderly women became infected with MAC, regardless of their body habitus.
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Aim: The purpose of the research was to test and validate an innovative and safe chemiluminescence method to evaluate sexual hormones in serum and plasma samples of Tursiops truncatus. Materials and Methods: The research was performed on 9 bottlenose dolphins entertained in Oltremare and in Zoomarine aquatic parks, sampled by the tail vein or from the ventral one and an ultrasound monitoring, throughout a 6 months period. Blood samples were analyzed using a chemiluminescence method. Data obtaine...
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#1D. Rebecca Prevots (NIH: National Institutes of Health)H-Index: 34
#2Theodore K. Marras (Toronto Western Hospital)H-Index: 11
Population-based data have documented a continued increase in NTM prevalence since 2000. Annual prevalence in North American and Australia ranges from 3.2鈥9.8 per 100,000, and is generally higher than in Europe. Studies of NTM PD from South Korea, Japan, and Taiwan, also suggest increasing prevalence. In Africa and the Middle East, prevalence of NTM ranges from 4% 鈥15% among suspected TB cases and 18%鈥20% among suspected multi-drug resistant TB (MDR TB) cases. M. avium complex (MAC) is predomina...
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Rationale: For unclear reasons, the phenotypical hosts for nontuberculous mycobacterial lung infection are often thin, elderly, white women without underlying lung disease. As these women are usually postmenopausal, we hypothesized that a state of relative hormone deficiency may predispose some women to pulmonary nontuberculous mycobacterial infection.Objectives: To conduct a prospective cross-sectional study to assess for alterations in systemic levels of sex hormones in patients with confirmed...
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#2Victorine Douin-Echinard (French Institute of Health and Medical Research)H-Index: 21
Last. Pierre Gourdy (French Institute of Health and Medical Research)H-Index: 43
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Short-term exposure to 17尾-estradiol (E2) in vitro has been reported to decrease the production of proinflammatory cytokines by LPS-activated macrophages through estrogen receptor 伪 (ER伪)-dependent activation of the PI3K pathway. In the present study, we confirm that in vitro exposure of mouse peritoneal macrophages to E2 enhanced Akt phosphorylation and slightly decreased LPS-induced cytokine production. In striking contrast, we show that chronic administration of E2 to ovariectomized mice mark...
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Abstract null null Nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasingly recognized in the U.S. and worldwide as a debilitating disease that is challenging to diagnose and manage. Beyond the principle task of recognizing the protean imaging manifestations of NTM-PD, radiologists will need to appropriately communicate with pulmonology and infectious disease colleagues in multidisciplinary management discussions. This update on nontuberculous mycobacteria (NTM) species, their cli...
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BACKGROUND The incidence of nontuberculous mycobacterial (NTM) infections has been increasing worldwide, becoming a significant healthcare burden especially among elderly people. This study aimed to evaluate the trends in NTM-associated mortality in Japan. METHODS This study used vital statistics data and data on all NTM-associated deaths (N=18,814) among individuals aged 鈮40 years in Japan from 1997 to 2016. We calculated the crude and age-adjusted mortality rates by age and sex and used joinpo...
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#1Yaoju TanH-Index: 2
#2Yunfeng Deng (SDU: Shandong University)H-Index: 5
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BACKGROUND We aimed to address the knowledge gap that exists regarding the epidemiological, demographic, and clinical characteristics of nontuberculous mycobacterial pulmonary diseases (NTM-PDs) among smear-positive patients with symptoms suggestive of pulmonary tuberculosis (PTB) in China. METHODS Prospective and national surveillance of NTM-PD was performed from 17 hospitals within the China Nontuberculous Mycobacteria Surveillance Study (CNTMS). Patients were eligible for inclusion if they ha...
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Nontuberculous mycobacterial (NTM) lung disease is one of a growing number of chronic health problems that is difficult to cure in aging societies. While it is important to be vigilant about associated comorbidities in order to provide better patient care, data on the prevalence of comorbidities stratified by country or region are scarce. We aimed to elucidate the comorbidities associated with NTM disease based on Japanese health insurance claims data. Cross-sectional analyses were performed usi...
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Background and objectives The number of patients with pulmonary Mycobacterium avium complex (MAC) disease is increasing worldwide, especially among middle-aged women and never-smokers. However, little is known about the factors causing exacerbations of pulmonary MAC disease in untreated patients. The aim of the present study was to identify the predictors of radiological aggravations of pulmonary MAC disease. Methods From April 2011 to December 2018, 238 MAC patients at our institute were newly ...
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#1Yoshifumi Uwamino (Keio: Keio University)H-Index: 10
#2Tomoyasu Nishimura (Keio: Keio University)H-Index: 16
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After publication of the original article [1], we were notified that units of testosterone in main text and abstract and units of DHEA-S in Fig. 1 and Table 4 are incorrect.
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