A unique case with positive anti‐myelin oligodendrocyte glycoprotein antibody presenting multiple brain lesions

Published on Mar 1, 2020in Neurology and Clinical Neuroscience
· DOI :10.1111/NCN3.12364
Namiko Matsumoto4
Estimated H-index: 4
(Okayama University),
Kota Sato17
Estimated H-index: 17
(Okayama University)
+ 9 AuthorsKoji Abe82
Estimated H-index: 82
(Okayama University)
📖 Papers frequently viewed together
1 Citations
2 Citations
#1Noriyuki Miyaue (Ehime University)H-Index: 6
#2Yuki Yamanishi (Ehime University)H-Index: 4
Last. Masahiro Nomoto (Ehime University)H-Index: 18
view all 7 authors...
Abstract A 20-year-old woman suffered right facial paralysis. The patient showed an abnormality in the perception of speech at an age of 25 years. At an age of 32 years, she developed acute headache and fever. Brain magnetic resonance imaging (MRI) showed an expanded high signal intensity lesion with gadolinium enhancement in the white matter of the left frontal lobe, which was suggestive of tumefactive demyelinating lesion (TDL). A brain tumor was suspected because TDL is a large demyelinating ...
6 CitationsSource
#1Kazuto Katsuse (UTokyo: University of Tokyo)H-Index: 1
#2Masanori Kurihara (UTokyo: University of Tokyo)H-Index: 5
Last. Tatsushi Toda (UTokyo: University of Tokyo)H-Index: 66
view all 12 authors...
Abstract Introduction Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have recently been associated with epilepsy with FLAIR hyperintense cortical lesions on MRI. Association between anti-MOG antibodies and epilepsy without detectable structural brain lesion on MRI is unknown. Case report A 48-year-old right-handed man with a four-and-a-half year history of anti-MOG antibody associated demyelinating disease presented with persistent global aphasia. Brain MRI showed no new lesion or cor...
12 CitationsSource
#1Kazuo Fujihara (Fukushima Medical University)H-Index: 71
#2Douglas Kazutoshi Sato (PUCRS: Pontifícia Universidade Católica do Rio Grande do Sul)H-Index: 27
Last. Masashi Aoki (Tohoku University)H-Index: 69
view all 13 authors...
Myelin oligodendrocyte glycoprotein (MOG) is localized at the outermost layer of the myelin sheath and is accessible for autoantibodies. Although experimental autoimmune encephalitis induced with MOG immunization has been studied for 30 years, the results of previous reports on MOG immunoglobulin G (IgG) detection with enzyme-linked immunosorbent assay and Western blot are confusing. However, after the development of human MOG-transfected cell-based assay to detect conformational-sensitive MOG-I...
14 CitationsSource
Objective We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination. Methods We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients. Results The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON...
234 CitationsSource
Abstract Background and objective Tumefactive demyelinating lesions (TDLs) are large inflammatory lesions that can mimic tumors or other space-occupying lesions. Differential diagnosis and management of these lesions remain challenging for neurologists. We aim to review the clinico-radiological features of patients with TDLs, as well as their management. Methods We performed a retrospective review of cases of TDLs treated in our center from January 2010 to February 2017. We reviewed the literatu...
25 CitationsSource
#1Alvaro Cobo-Calvo (French Institute of Health and Medical Research)H-Index: 13
#2Anne Ruiz (French Institute of Health and Medical Research)H-Index: 10
Last. Romain Marignier (French Institute of Health and Medical Research)H-Index: 29
view all 11 authors...
Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been reported in acute demyelinating encephalomyelitis (ADEM), optic neuritis (ON), and neuromyelitis optica spectrum disorders (NMOSD) in adults and pediatrics. We aimed to delineate the common features of MOG-Ab-related disorders in children and adults, and report uncommon presentations. Twenty-seven consecutive pediatric and adult patients testing positive for MOG-Ab, with a minimum follow-up of 6 months, were included. Comprehensiv...
71 CitationsSource
#1Ryo OgawaH-Index: 7
#2Ichiro NakashimaH-Index: 57
Last. Kazuo FujiharaH-Index: 71
view all 12 authors...
OBJECTIVE: To describe the features of adult patients with benign, unilateral cerebral cortical encephalitis positive for the myelin oligodendrocyte glycoprotein (MOG) antibody. METHODS: In this retrospective, cross-sectional study, after we encountered an index case of MOG antibody-positive unilateral cortical encephalitis with epileptic seizure, we tested for MOG antibody using our in-house, cell-based assay in a cohort of 24 consecutive adult patients with steroid-responsive encephalitis of u...
199 CitationsSource
#1Claudia F. Lucchinetti (Mayo Clinic)H-Index: 85
#2R. H. Gavrilova (GAU: University of Göttingen)H-Index: 1
Last. Wolfgang Brück (GAU: University of Göttingen)H-Index: 99
view all 16 authors...
Atypical imaging features of multiple sclerosis lesions include size >2 cm, mass effect, oedema and/or ring enhancement. This constellation is often referred to as ‘tumefactive multiple sclerosis’. Previous series emphasize their unifocal and clinically isolated nature, however, evolution of these lesions is not well defined. Biopsy may be required for diagnosis. We describe clinical and radiographic features in 168 patients with biopsy confirmed CNS inflammatory demyelinating disease (IDD). Les...
318 CitationsSource
Cited By1