Bioorthogonal human milk oligosaccharide probes for antimicrobial target identification within Streptococcus agalactiae
Abstract
Human milk oligosaccharides (HMOs) are a structurally diverse class of carbohydrates that possess strong antibacterial activity against Streptococcus agalactiae (Group B Strep, GBS). This work highlights the design, synthesis, and retained biological activity of several HMO bioorthogonal probes within GBS, a first in class advance. The use of such probes will assist in identifying HMO-protein interactions within GBS and may be broadly applicable...
Paper Details
Title
Bioorthogonal human milk oligosaccharide probes for antimicrobial target identification within Streptococcus agalactiae
Published Date
Feb 1, 2020
Journal
Volume
488
Pages
107895 - 107895
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