Catechol‐O‐Methyltransferase and Cardiovascular Disease: MESA

Background Genetic variation in catechol‐O‐methyltransferase ( COMT ), a key enzyme in estrogen and catecholamine metabolism, has plausible physiological links to cardiovascular disease ( CVD ) and its risk factors. In WHS (Women's Health Study), COMT variants rs4818 and rs4680 were associated with a lower risk of CVD among women receiving placebo but not aspirin, suggesting a possible role of COMT in thrombosis. Methods and Results To evaluate...