Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

Volume: 10, Issue: 1, Pages: 5546
Published: Dec 5, 2019
Abstract
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately mimic the complexity of the...
Paper Details
Title
Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4
Published Date
Dec 5, 2019
Volume
10
Issue
1
Pages
5546
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