Herb–Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats

Licorice is the dried roots and rhizomes of Glycyrrhiza uralensis Fisch (Leguminosae), which is often used with paclitaxel to alleviate paclitaxel-induced pain in clinics. However, the herb–drug interaction between licorice and paclitaxel is still unknown. Our study evaluates the effects of oral licorice on the paclitaxel in rats via pharmacokinetic studies. A simple and rapid ultra-high-performance liquid chromatography-tandem mass spectrometry...