GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer
Abstract
TERT promoter mutations occur in the majority of glioblastoma, bladder cancer (BC), and other malignancies while the ETS family transcription factors GABPA and its partner GABPB1 activate the mutant TERT promoter and telomerase in these tumors. GABPA depletion or the disruption of the GABPA/GABPB1 complex by knocking down GABPB1 was shown to inhibit telomerase, thereby eliminating the tumorigenic potential of glioblastoma cells. GABPA/B1 is thus...
Paper Details
Title
GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer
Published Date
Dec 4, 2019
Journal
Volume
27
Issue
6
Pages
1862 - 1877
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Notes
History