Original paper

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Volume: 16, Issue: 1
Published: Dec 1, 2019
Abstract
Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals. Here, we characterize the CSF EV proteome in HIV+ subjects and its relationship to neuroinflammation, stress responses, and HIV-associated neurocognitive disorders (HAND).CSF EVs isolated from 20 HIV+ subjects with (n = 10) or without (n = 10) cognitive impairment were...
Paper Details
Title
Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment
Published Date
Dec 1, 2019
Volume
16
Issue
1
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