A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis

Refractory periapical periodontitis, which is a persistent infection after root canal treatment, still has no effective treatment. Its most common pathogen is Enterococcus faecalis . Here, the precursor of phytosteroids, dioscin, is introduced to fight against the inflammation induced by Enterococcus faecalis . The findings suggest that dioscin inhibits the nuclear transport of NF‐κB and the expression of reactive oxygen species (ROS) induced by...