Cancer Susceptibility Mutations in Patients With Urothelial Malignancies

Urothelial cancers (UCs) have a substantial hereditary component, but, other than their association with Lynch syndrome, the contribution of genetic risk factors to UC pathogenesis has not been systematically defined. We sought to determine the prevalence of pathogenic/likely pathogenic (P/LP) germline variants in patients with UC and identify associated clinical factors.Overall, 586 patients with UC underwent prospective, matched tumor-normal...